关键词: 维甲酸, 胎鼠, 致畸性, Cyp26b1基因

Abstract: Retinoic acid is a metabolic intermediate of vitamin A in animals. It plays an important role in the growth and development of vertebrates, especially in embryonic development. In this study, the effects of retinoic acid on skeletal development at different doses and different embryonic time were studied. The expression level of Cyp26b1 gene was further detected to explore the mechanism of teratogenicity. The results showed that the degree of teratogenicity of skeletons was dose-dependent, and the teratogenic sites of skeletons varied with exposure time. Retinoic acid could cause decrease of the  expression level of Cyp26b1 gene. Retinoic acid can lead to skeletal malformation, which may be caused by the expression changes of Cyp26b1 gene.

Key words: retinoic acid, fetal rat, teratogenicity, Cyp26b1 gene