湿性愈合研究进展

doi:10.19586/j.2095-2341.2023.0010

生物技术进展 ›› 2023, Vol. 13 ›› Issue (4): 534-541.DOI: 10.19586/j.2095-2341.2023.0010

• 进展评述 • 上一篇

湿性愈合研究进展

刘子怡(), 张旭娟, 蔡子松, 马晨, 刘梦昱, 赵鹏翔()

北京工业大学环境与生命学部，北京 100124

收稿日期:2023-02-03 接受日期:2023-03-31 出版日期:2023-07-25 发布日期:2023-08-03
通讯作者: 赵鹏翔
作者简介:刘子怡 E-mail: LiuZY-Bjut@bjut.edu.cn；
基金资助:
军委后勤保障部开放研究重点项目(BHJ17L018)

Progress on Moist Healing Research

Ziyi LIU(), Xujuan ZHANG, Zisong CAI, Chen MA, Mengyu LIU, Pengxiang ZHAO()

Faculty of Environment and Life，Beijing University of Technology，Beijing 100124，China

Received:2023-02-03 Accepted:2023-03-31 Online:2023-07-25 Published:2023-08-03
Contact: Pengxiang ZHAO

摘要/Abstract

摘要：

创面愈合是从组织破损恢复至原形态功能的过程，包含凝血、炎症、增殖、重塑多个阶段。常规的创面愈合多为干性愈合，以血小板凝集形成血痂覆盖于创口表面为特征，并易于形成疤痕。创面湿度过高，则造成慢性难愈创面。湿性愈合疗法通过维持合适的湿度改善创面微环境，促进多种细胞、因子的协同作用，提高了创面愈合速度和效果，避免了创面结痂并减少溃疡面的形成，因而在临床治疗中被广泛应用。对湿性愈合的发展、湿性疗法的治疗机制进行了综述，总结了以湿性愈合理论为基础的医用敷料的临床应用，并对湿性愈合疗法的未来发展方向进行了展望。

关键词: 湿性愈合, 治疗机制, 医用敷料

Abstract:

Wound healing is the process of restoring tissue damage to its original morphological function， including coagulation， inflammation， proliferation， and remodeling. Conventional wound healing is mostly dry healing， characterized by platelet agglutination forming a blood scab covering the wound surface， and prone to scarring. If the wound is too humid， it will cause a chronic and difficult wound. Moist healing therapy is widely used in clinical treatment by maintaining suitable humidity to improve the wound microenvironment， promote the synergistic effect of various cells and factors， improve the wound healing speed and effect， avoid wound scabs and reduce the formation of ulcer surfaces. This paper reviewed the development of moist healing and the therapeutic mechanism of moist therapy， summarized the clinical application of medical dressings based on moist healing theory， and looked forward to the future development direction of moist healing therapy.

Key words: moist healing, therapeutic mechanisms, medical dressings

中图分类号:

R318

刘子怡, 张旭娟, 蔡子松, 马晨, 刘梦昱, 赵鹏翔. 湿性愈合研究进展[J]. 生物技术进展, 2023, 13(4): 534-541.

Ziyi LIU, Xujuan ZHANG, Zisong CAI, Chen MA, Mengyu LIU, Pengxiang ZHAO. Progress on Moist Healing Research[J]. Current Biotechnology, 2023, 13(4): 534-541.

图/表 2

图1 3种不同湿度微环境的创伤愈合方式A：干性愈合，伤口表面覆盖有血痂，在创面愈合的过程中，血痂逐渐收缩；B：湿性愈合，伤口表面覆盖有敷料可以营造湿润的环境，肉芽组织在敷料下方生长；C：溃疡伤口，新生组织受到破坏后久治不愈

Fig. 1 Wound healing methods in three different humidity microenvironments

图2 湿性愈合中多细胞、酶及因子的协同作用示意图

Fig. 2 Synergistic diagram of multi-cell, enzyme and factor synergy in moist healing

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湿性愈合研究进展

Progress on Moist Healing Research

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