关键词: 紫杉醇产生菌, 红豆杉内生菌, 非红豆杉内生真菌, 腐生真菌

Abstract: Paclitaxel is a diterpenic polyoxygenated pseudoalkaloid, which has a widespread medicinal value and its anticancer mechanism is unique, so it is recognized as one of the best antitumor agents. Using the microorganism fermentation method to produce taxol maybe an ideal way to solve the drug resources shortage in the future. This paper introduced the medicinal value and antitumor mechanism, summarized recent advances in biodiversity and its source of taxol-producing microorganisms. At last the paper also made a forecast of the future prospects on taxol-producing microorganism, which was expected to provide reference for research and development of taxol drug.

Key words: taxol-producing microorganism, Taxus endophytes, non Taxus endophytic fungi, soil saprophytic fungi