关键词: 聚谷氨酸, 药物载体, 疫苗佐剂, 粘合剂, 组织工程材料, 造影剂

Abstract: Poly γ-glutamic acid (γ-PGA) is a naturally occurring poly amino acids with characteristics of water solubility, biocompatibility, biodegradability and non-toxicity towards human and the environment. Thus, it can be used as a green and environmental friendly biological material. γ-PGA and its derivatives offer a wide range of applications in medicine including being used as drug carriers, vaccine adjuvant, biological adhesives, tissue engineering materials and so on. These new complex and tissue engineering materials exhibit excellent biocompatibility, lower toxicity, high drug target-orientation and good drug efficacy which make it a broad application prospect. These applications of γ-PGA in medicine are reviewed in this article to give some references for the further research and commercial uses.

Key words: polyglutamic acid (γ-PGA), drug carrier, biological adhesive, vaccine adjuvant, tissue engineering material, contrast agent