关键词: BiTE（T-细胞的双特异抗体）, 双特异性抗体, 免疫治疗, 组织再生

Abstract: Rapid development of gene engineering has led to the success of the new type of bispecific antibody drugs. At present, the application of dual bispecific antibody drugs was in tumor immunotherapy, autoimmune diseases, infectious diseases, tissue regeneration and clinical diagnosis. In this paper, the brief development history was introduced, and applications of bispecific antibodies in immunological therapy, tissue regeneration and clinical diagnosis were reviewed. At last, development prospect was forecasted. The paper was expected to provided reference for the research and development of new bispecific antibody drugs.

Key words: BiTE (bispecific T cell engager), bispecific antibodies, immunotherapy, regenerative medicine