关键词: 正常胚胎, 核移植胚胎, 染色体结构变化, 组蛋白置换

Abstract: In this paper, we introduced biological morphological change during development of normal embryos and cloned embryos, elaborated the difference from the morphological and molecular mechanism between the two, and summed up the main factors which impact the development of reconstruction of nuclear transfer embryos. Moreover, we disscussed morphology in the cells focused on chromosome structural changes to the effect of egg reprogramming, at the molecular level the replacement between the egg histone and the cell histone, in theory, to provide a reference to improve the efficiency of nuclear transfer.

Key words: normal embryos, cloned embryos, chromosome structural changes, histone replacement