磁适配体生物传感器

doi:10.19586/j.2095-2341.2022.0199

生物技术进展 ›› 2023, Vol. 13 ›› Issue (3): 339-344.DOI: 10.19586/j.2095-2341.2022.0199

磁适配体生物传感器

康帅帅¹^,²(), 王瑞安², 许文涛², 朱龙佼²()

^1.中国农业大学食品科学与营养工程学院，北京 100083
^2.中国农业大学营养与健康系，食品精准营养与质量控制教育部重点实验室，北京 100193

收稿日期:2022-11-21 接受日期:2023-03-03 出版日期:2023-05-25 发布日期:2023-06-12
通讯作者: 朱龙佼
作者简介:康帅帅E-mail: kang9298ss@163.com;
基金资助:
北京市景观休闲农业创新团队项目(BAIC09-2022)

Magnetic Aptamer Biosensors

Shuaishuai KANG¹^,²(), Ruian WANG², Wentao XU², Longjiao ZHU²()

^1.College of Food Science and Nutritional Engineering，China Agricultural University，Beijing 100083，China
^2.Key Laboratory of Precision Nutrition and Food Quality，Department of Nutrition and Health，China Agricultural University，Beijing 100193，China

Received:2022-11-21 Accepted:2023-03-03 Online:2023-05-25 Published:2023-06-12
Contact: Longjiao ZHU

摘要/Abstract

摘要：

磁珠（magnetic beads,MBs）是具有磁性的微小球形颗粒，在将分析物从复杂基质中分离出来以及固定配体等方面发挥关键作用。为了获得不同的识别及信号输出性能，MBs可以与各种反应基团进行功能化并发挥相应作用。对磁珠的性质、制备方法、功能化改性与搭载适配体的应用等方面进行了全面综述，总结了磁生物传感器所表现出的准确性、及时性、便携性、低成本，及在痕量水平上的信号放大等优势。最后，提出了磁珠潜在的应用挑战和未来方向。

关键词: 磁珠, 适配体, 制备方法, 核酸传感器

Abstract:

Magnetic beads （MBs） are small spherical particles with magnetism， which plays a key role in separating analytes from complex matrices and fixing ligands. In order to obtain different recognition and signal output performance， MBs can be functionalized with various reaction groups to play a corresponding role. In this review， we reviewed the properties， preparation methods， functional modification and application of carrying adapters of magnetic beads. The advantages of magnetic biosensors， such as the accuracy， timeliness， portability and low cost as well as the signal amplification at the trace level， were summa-rized. Finally， the potential application challenges and future directions of magnetic beads were proposed.

Key words: magnetic bead, aptamer, preparation method, nucleic acid sensor

中图分类号:

S951.4+2

康帅帅, 王瑞安, 许文涛, 朱龙佼. 磁适配体生物传感器[J]. 生物技术进展, 2023, 13(3): 339-344.

Shuaishuai KANG, Ruian WANG, Wentao XU, Longjiao ZHU. Magnetic Aptamer Biosensors[J]. Current Biotechnology, 2023, 13(3): 339-344.

图/表 1

参考文献 40

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磁适配体生物传感器

Magnetic Aptamer Biosensors

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