富氢水和富氢生理盐水生物医学研究进展——临床试验

doi:10.19586/j.2095-2341.2021.0180

生物技术进展 ›› 2022, Vol. 12 ›› Issue (3): 344-351.DOI: 10.19586/j.2095-2341.2021.0180

富氢水和富氢生理盐水生物医学研究进展——临床试验

仪杨(), 赵鹏翔, 刘梦昱, YAO Mawulikplimi Adzavon, 谢飞(), 马雪梅

北京工业大学环境与生命学部，北京 100124

收稿日期:2021-11-15 接受日期:2021-12-03 出版日期:2022-05-25 发布日期:2022-05-26
通讯作者: 谢飞
作者简介:仪杨 E-mail：yiyangxiufeng@emails.bjut.edu.cn；
基金资助:
军委后勤保障部开放研究重点项目(BHJ17L018)

Biomedical Research Progress of Hydrogen⁃rich Water and Hydrogen⁃rich Saline: Clinical Trial

Yang YI(), Pengxiang ZHAO, Mengyu LIU, Mawulikplimi Adzavon YAO, Fei XIE(), Xuemei MA

Faculty of Environment and Life，Beijing University of Technology，Beijing 100124，China

Received:2021-11-15 Accepted:2021-12-03 Online:2022-05-25 Published:2022-05-26
Contact: Fei XIE

摘要/Abstract

摘要：

氢分子已被证实具有广泛的生物学效应，研究表明，氢气对多种疾病具有显著的治疗作用。近年来，国内外关于氢分子临床应用的报道较多，为疾病治疗提供了新的途径。饮用富氢水或注射富氢生理盐水是常用的氢气摄入方式，因其摄入简单、安全性高得到了临床广泛地关注。主要综述了富氢水在代谢性疾病、神经系统疾病、炎症性疾病、肿瘤、皮肤病及运动疲劳等的临床研究进展，旨在为富氢水和富氢生理盐水的临床应用及作用机制研究提供理论参考。

关键词: 富氢水, 富氢生理盐水, 临床试验

Abstract:

Hydrogen molecular has been verified to have a wide range of biological effects， and previous studies showed that hydrogen has a significant therapeutic effect on many diseases. In recent years， there are many reports about the clinical application of hydrogen molecules at home and abroad， which provided a new way to treat diseases. Drinking hydrogen-rich water or injecting hydrogen-rich saline are the commonly used methods for hydrogen intake. It has attracted extensive attention because of its simple operation and high safety. In this paper， the clinical research progress of hydrogen-rich water and hydrogen-rich saline in metabolic diseases， nervous system diseases， inflammatory diseases， tumors， skin diseases， and exercise fatigue were summerized， aiming to provide references for clinical application and mechanism research of hydrogen-rich water and hydrogen-rich saline.

Key words: hydrogen-rich water, hydrogen-rich saline, clinical trial

中图分类号:

R313

仪杨, 赵鹏翔, 刘梦昱, YAO Mawulikplimi Adzavon, 谢飞, 马雪梅. 富氢水和富氢生理盐水生物医学研究进展——临床试验[J]. 生物技术进展, 2022, 12(3): 344-351.

Yang YI, Pengxiang ZHAO, Mengyu LIU, Mawulikplimi Adzavon YAO, Fei XIE, Xuemei MA. Biomedical Research Progress of Hydrogen⁃rich Water and Hydrogen⁃rich Saline: Clinical Trial[J]. Current Biotechnology, 2022, 12(3): 344-351.

参考文献 39

1	OHSAWA I, ISHIKAWA M, TAKAHASHI K, et al.. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals[J]. Nat. Med., 2007, 13(6): 688-694.
2	TAO G, SONG G, QIN S. Molecular hydrogen: current knowledge on mechanism in alleviating free radical damage and diseases[J]. Acta Biochim. Biophys. Sin.,2019, 51(12): 1189-1197.
3	杨兆娜,乔瑞,张宇童,等.氢分子生物医学研究进展[J].标记免疫分析与临床,2014,21(6):752-755.
4	李佳腊,张亚婷,谢飞.氢分子在癌症防治中的应用进展[J].生物技术进展,2016,6(3):174-178.
5	王濛,仪杨,孙梦婷,等.富氢水和富氢生理盐水生物医学研究进展——动物实验[J].生物技术进展,2022,12(3):332-343.
6	寻治铭,赵清辉,琚芳迪,等.氢分子在临床应用中的研究进展[J].生物技术进展,2019,9(3): 217-222.
7	KAJIYAMA S, HASEGAWA G, ASANO M, et al.. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance[J]. Nutr. Res., 2008, 28(3): 137-143.
8	OGAWA S, OHSAKI Y, SHIMIZU M, et al.. Electrolyzed hydrogen-rich water for oxidative stress suppression and improvement of insulin resistance: a multicenter prospective double-blind randomized control trial[J] Diabetol. Int., 2021, 13(1): 209-219.
9	周晓.氢气对社区糖尿病患者氧化应激的作用及影响因素[J].社区医学杂志,2018,(12):1-3.
10	NAKAO A T Y, SHARMA P, EVANS M, et al.. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study[J]. J. Clin. Biochem. Nutr., 2010, 46(2): 140-149.
11	SONG G, LI M, SANG H, et al.. Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome[J]. J. Lipid Res., 2013, 54(7): 1884-1893.
12	LEBARON T W, SINGH R B, FATIMA G, et al.. The effects of 24-week, high-concentration hydrogen-rich water on body composition, blood lipid profiles and inflammation biomarkers in men and women with metabolic syndrome: a randomized controlled trial[J]. Diabetes Metab. Syndr. Obes., 2020, 13: 889-896.
13	郑延松,韩超进,陈志来,曾强.氢气对男性高尿酸血症治疗效果的研究[J].中国临床保健杂志,2017,20(2):118-121.
14	KOROVLJEV D, STAJER V, OSTOJIC J, et al.. Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial[J]. Clin. Res. Hepatol. Gastroenterol., 2019, 43(6): 688-693.
15	KOROVLJEV D, TRIVIC T, DRID P, et al.. Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women[J]. Ir. J. Med. Sci., 2018, 187(1): 85-89.
16	ASADA R, SAITOH Y, MIWA N. Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles[J]. Med. Gas. Res., 2019, 9(2): 68-73.
17	ONO H, NISHIJIMA Y, ADACHI N, et al.. Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study[J]. Med. Gas. Res., 2011, 1(1): 1-12.
18	NAGATANI K, TAKEUCHI S, TOMURA S, et al.. Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies[J]. Med. Gas. Res., 2013, 3(13): 1-7.
19	YANG L, LI D, CHEN S. Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy[J]. Open Med. (Wars), 2016, 11(1): 399-406.
20	TAKEUCHI S, KUMAGAI K, TOYOOKA T, et al. Intravenous hydrogen therapy with intracisternal magnesium sulfate infusion in severe aneurysmal subarachnoid hemorrhage[J]. Stroke, 2021, 52(1): 20-27.
21	YORITAKA A, TAKANASHI M, HIRAYAMA M, et al.. Pilot study of H₍₂₎ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial[J]. Mov. Disord., 2013, 28(6): 836-839.
22	王晓英,许长春.富氢水治疗帕金森病64例临床研究[J].海军医学杂志,2021,42(1):108-109.
23	HONG C T, HU C J, LIN H Y, et al.. Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: a pilot study[J]. Medicine (Baltimore), 2021, 100(4): 1-6.
24	NISHIMAKI K, ASADA T, OHSAWA I, et al.. Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment[J]. Curr. Alzheimer Res., 2018, 15(5): 482-492.
25	MIZUNO K, SASAKI A T, EBISU K, et al.. Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life[J]. Med. Gas. Res., 2017, 7(4): 247-255.
26	金玲.富氢盐水鼻腔灌洗中重度持续性变应性鼻炎的临床研究[J].临床耳鼻咽喉头颈外科杂志,2018(7):493-496.
27	ISHIBASHI T, SATO B, SHIBATA S, et al.. Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study[J]. Int. Immunopharmacol., 2014, 21(2): 468-473.
28	于盈盈,苏励,杨光辉,等.富氢水疗缓解强直性脊柱炎疼痛的临床观察[J].中国康复医学杂志,2019,34(2):192-193.
29	XIA C, LIU W, ZENG D, et al.. Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B[J]. Clin. Transl. Sci., 2013, 6(5): 372-375.
30	MATSUMOTO S, UEDA T, KAKIZAKI H. Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome[J]. Urology, 2013, 81(2): 226-230.
31	KANG K M, KANG Y N, CHOI I B, et al.. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors[J]. Med. Gas. Res., 2011, 1(1): 1-11.
32	YANG Q, JI G, PAN R, et al.. Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy[J]. Mol. Clin. Oncol., 2017, 7(5): 891-896.
33	LI Q, KATO S, MATSUOKA D, et al.. Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro[J]. Med. Gas. Res., 2013, 3(1): 3-20.
34	ISHIBASHI T, ICHIKAWA M, SATO B, et al.. Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases[J]. Mol. Med. Rep., 2015, 12(2): 2757-2764.
35	ZHU Q, WU Y, LI Y, et al.. Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques[J]. Sci. Rep., 2018, 8(1): 1-8.
36	AOKI K N A, ADACHI T, MATSUI Y, et al.. Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes[J]. Med. Gas. Res., 2012, 2(12):1-6.
37	李晨.富氢水对重复力竭运动后血乳酸化程度缓解机制研究[J].泰山医学院学报,2015,36(10):1093-1095.
38	LEBARON T L A, OHTA S, MIKAMI T, et al.. Acute supplementation with molecular hydrogen benefits submaximal exercise indices. randomized, double-blinded, placebo-controlled crossover pilot study[J]. J. Lifestyle Med., 2019, 9(1): 36-43.
39	MIKAMI T T K, LEE H, LEE H, et al.. Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study 1[J]. Can. J. Physiol. Pharmacol., 2019, 97(9): 857-862.

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富氢水和富氢生理盐水生物医学研究进展——临床试验

Biomedical Research Progress of Hydrogen⁃rich Water and Hydrogen⁃rich Saline: Clinical Trial

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