关键词: 新城疫, 传统疫苗, 载体疫苗, 纳米粒子, 免疫佐剂

Abstract: Newcastle disease (ND) is one of the viral diseases of poultry, which can cause damage to nervous system, digestive system and respiratory system of poultry, with a mortality rate as high as 30%, which severely restricts poultry breeding. Therefore, it is of great economic significance to study ND. Rational use of vaccines is the main method to prevent and control Newcastle disease. Since 1950, live attenuated and inactivated Newcastle disease vaccines have been widely used, and then vector vaccines have entered the commercial application stage. In addition, the choice of vaccine adjuvant and the optimization of delivery route have also entered the researchers’ field of vision. Based on this situation, the research and development status and prospect of traditional vaccine, vector vaccine and virus-like particle vaccine for Newcastle disease  were analyzed, and the application progress of nanoparticles and new immune adjuvant in the research and development of Newcastle disease vaccine was introduced. Then the common commercial vaccines of Newcastle disease at home and abroad were summarized, aiming to provide references for developing more efficient and cheap Newcastle disease vaccine, and further control the spread of Newcastle disease epidemic.

Key words: Newcastle disease, conventional vaccines, carrier vaccines, nanoparticles, immune adjuvant