关键词: 自组装蛋白, 重组铁蛋白, 纳米疫苗

Abstract: Self-assembled proteins are ubiquitous in eukaryotic and prokaryotic cells, and they are important for living organisms to maintain the normal operation, and even related to the evolution of living organisms. Common self-assembled proteins include virus particles, serum albumin, silk protein and ferritin. Among them, ferritin can form nanomaterials with uniform particle size and good biocompatibility. It also has unique physical and chemical properties, such as pH sensitivity, high temperature tolerance, and resistance to most denaturants, so as to control the self-assembly characteristics of ferritin by pH regulation. Ferritin is a natural protein found in most living organisms, and it has a broad application prospect in tumor diagnostic imaging and therapy, drug carrier and nano-vaccine. The bionic synthesis of ferritin and its application in nano-vaccine were mainly discussed in order to provide references for the research and development of novel animal nano-vaccine.

Key words: self-assembled protein, recombinant ferritin, nano-vaccine