关键词: 胶质母细胞瘤, 表皮生长因子受体, 异柠檬酸脱氢酶1/2, 1p19q, 端粒酶反转录酶, 免疫关卡蛋白, microRNA, 影像学生物标志物

Abstract: As one of the common primary malignant tumor in central nerve system, glioblastoma(GBM) demonstrates poor prognosis with 14 months of median survival. Higher recurrence is one of the characters of GBM after treatment. The reason for absence of effective therapy of GBM is our poor understanding of tumor biology and mechanism of GBM. As a consequence , it is necessary that comprehensively understanding molecular markers of GBM to improve clinical outcome. This review introduced GBM markers such as EGFR, IDH1/2 and 1p19q as well as imaging biomarkers and immune checkpoints. Accurate classification of GBM and personalized treatment was developed based on these markers. Furthermore,  the relevant cancer pathway gives a chance to develop the target treatment and improve the GBM patient survival.

Key words: glioblastoma, epidermal growth factor receptor, isocitrate dehydrogenase 1/2, 1p19q, telomerase reverse transcriptase, immune checkpoints, microRNA, imaging biomarkers