关键词: RNA降解体, RNA分子伴侣Hfq, 非编码RNA, RNA稳定性, 内切核酸酶

Abstract: The primary executioner of RNA degradation in bacteria is a muti-enzyme complex, namely RNA degradosome, which is composed of RNA helicase, polynucleotide phosphorylase (PNPase), ribonuclease E (RNase E) and two enzymes in glycolysis route (enolase and phosphofructokinase). The function of the complex is involving with the processing of ribosome RNA (rRNA) and decay of messenger RNA (mRNA). Besides, RNA chaperone Hfq and regulatory small RNA (sRNA) also play important roles in the regulation of RNA stability. The progress on the functional elements in RNA stability regulation, especially the degradative enzymes of RNA degradosome and the RNA chaperone Hfq, was surveyed in order to provide theoretical knowledge for studying the stability of bacterial RNA and its regulation.

Key words: RNA degradosome, RNA chaperone Hfq, non-coding RNA, RNA stability, ribonuclease E