Myostatin基因突变激发骨骼肌发育机制研究进展

doi:10.19586/j.2095-2341.2021.0053

生物技术进展 ›› 2021, Vol. 11 ›› Issue (4): 476-482.DOI: 10.19586/j.2095-2341.2021.0053

Myostatin基因突变激发骨骼肌发育机制研究进展

高丽¹(), 杨磊², 李光鹏²()

^1.包头师范学院生物科学与技术学院，内蒙古包头 014030
^2.内蒙古大学生命科学学院，省部共建草原家畜生殖调控与繁育国家重点实验室，呼和浩特 010030

收稿日期:2021-04-19 接受日期:2021-06-07 出版日期:2021-07-25 发布日期:2021-08-02
通讯作者: 李光鹏
作者简介:高丽 E-mail: gaoli8905@163.com；
基金资助:
内蒙古自治区科技重大专项项目(2020ZD0008);包头市青年创新人才项目(2010)

Research Progress on the Mechanism of Skeletal Muscle Development Stimulated by Myostatin Gene Mutation

Li GAO¹(), Lei YANG², Guangpeng LI²()

^1.School of Biology Science and Technology，Baotou Teacher’s College，Inner Mongolia Baotou 014030，China
^2.State Key Laboratory of Reproductive Regulation & Breeding of Grassland Livestock，College of Life Sciences，Inner Mongolia University，Hohhot 010030，China

Received:2021-04-19 Accepted:2021-06-07 Online:2021-07-25 Published:2021-08-02
Contact: Guangpeng LI

摘要/Abstract

摘要：

肌肉生长抑制素基因（myostatin，MSTN）是骨骼肌发育的负调节因子，在不同物种中具有高度保守性。自然突变或通过基因编辑技术对该基因进行操作，均可以获得肌肉异常发达的动物个体。研究表明，MSTN基因突变可以通过多种调控途径影响肌肉发育过程。因此，从成肌细胞增殖、分化、蛋白质合成分解代谢、组蛋白修饰以及巨噬细胞极化等5个方面对MSTN突变促进肌肉发育的机理进行综述，以期为农业动物育种新材料生产及重大恶病质的治疗提供借鉴。

关键词: 基因突变, 细胞增殖, 蛋白质合成, 组蛋白修饰, 巨噬细胞极化

Abstract:

Myostatin （MSTN） is a negative regulator of skeletal muscle development， which is highly conserved among different species. Animal individuals with abnormally developed muscles can be obtained by natural mutation or manipulation of the gene by gene editing technology. Studies have shown that MSTN gene mutation can affect muscle development through various regulatory approaches. Therefore， the mechanism of MSTN mutation promoting muscle development was reviewed from five aspects， such as myoblast proliferation， differentiation， protein synthesis and catabolism， histone modification and macrophage polarization， in order to provide reference for the production of new materials for agricultural animal breeding and the treatment of major cachexia.

Key words: gene mutation, cell proliferation, protein synthesis, histone modification, macrophage polarization

中图分类号:

高丽, 杨磊, 李光鹏. Myostatin基因突变激发骨骼肌发育机制研究进展[J]. 生物技术进展, 2021, 11(4): 476-482.

Li GAO, Lei YANG, Guangpeng LI. Research Progress on the Mechanism of Skeletal Muscle Development Stimulated by Myostatin Gene Mutation[J]. Current Biotechnology, 2021, 11(4): 476-482.

图/表 1

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Myostatin基因突变激发骨骼肌发育机制研究进展

Research Progress on the Mechanism of Skeletal Muscle Development Stimulated by Myostatin Gene Mutation

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