关键词: 发育性髋关节发育不良, 易感基因, 软骨细胞, GDF5

Abstract: Developmental dysplasia of the hip (DDH) is an unstable joint disease mainly caused by structural deformities of acetabulum, proximal femur and joint capsule, which develops into dislocation of the hip. Dysplasia of cartilage in the hip joint, abnormal bones and tendons  can lead to structural deformity of the hip joint, and eventually lead to DDH. Therefore, early prevention and diagnosis is the key to DDH treatment. Researches show that DDH has genetic basis, and its susceptible genes include GDF5, HOXD9, COL2AL, PAPPA2, etc. Among them, growth differentiation factor 5 (GDF5) plays an important role in the proliferation and differentiation of chondrocytes, which is one of the hot spots in the treatment of DDH at present. Therefore, understanding the effect of GDF5 gene on cartilage development and differentiation is of great significance for the pathogenesis and treatment of DDH. Based on this, the progress of influence of GDF5 on DDH at the gene level was discussed recently at home and abroad, and the treatment schemes based on GDF5 such as intra-articular injection of recombinant human GDF5 were reviewed, in order to provide new strategies for clinical treatment of DDH.

Key words: developmental dysplasia of the hip, susceptibility gene, chondrocyte, GDF5