生物技术进展 ›› 2011, Vol. 1 ›› Issue (3): 165-171.DOI: 10.3969/j.issn.2095-2341.2011.03.03

• 进展评述 • 上一篇    下一篇

棉酚及其衍生物合成途径的研究进展

张程程,吴燕民,唐益雄*   

  1. 中国农业科学院生物技术研究所, 北京 100081
  • 收稿日期:2011-05-26 出版日期:2011-09-25 发布日期:2011-06-15
  • 通讯作者: 唐益雄,研究员,博士,研究方向为植物生物化学与分子生物学。Tel:010-82106113; E-mail:tangyx@mail.caas.net.cn
  • 作者简介:张程程,硕士研究生,研究方向为植物基因工程。E-mail:zhangchengcheng23@yahoo.cn。
  • 基金资助:

    国家转基因生物新品种培育重大专项(2008ZX08005-004)资助。

Progress on Biosynthetic Pathway of Gossypol and its Derivatives

ZHANG Cheng-cheng, WU Yan-min, TANG Yi-xiong   

  1. Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
  • Received:2011-05-26 Online:2011-09-25 Published:2011-06-15

摘要: 棉酚作为一种倍半萜烯类植物抗菌素广泛存在于棉花的根、种子等表皮组织的色素腺体里。该化合物已在医药、工业和农业等领域得到广泛应用。近来对棉酚及其衍生物合成途径的研究日趋深入,许多关键酶基因已得到克隆和分析。掌握棉酚及其衍生物的生物合成途径,并试图通过基因工程改造的方法来控制植物体棉酚的合成具有重要意义。概述了棉酚及其衍生物合成途径和关键酶的研究进展并展望其应用前景。

关键词: 棉酚, 倍半萜烯类植物抗菌素, MVA途径, DXP途径, 色素腺体

Abstract: Gossypol, one kind of sesquiterpene phytoalxins, which is synthesized in pigment glands of cotton outer tissues such as root and seed,has been widely applied in medical, industrial and agricultural areas. Recently, studies on biosynthesis of gossypol and its derivatives have made a great progress and many key enzymes have been cloned and characterized. It is of significance to understand the biosynthetic pathway and to mannually control gossypol content with genetic modification. This paper reviews the researh progress in biosynthetic parthway of gossypol, its derivatives, and relative key enzymes; prospects the application of gossypol in all fields.

Key words: gossypol, sesquiterpene phytoalxins, MVA pathway, DXP pathway, pigment glands