关键词: 葡聚糖硫酸钠, 溃疡性结肠炎, 造模现状, 机制研究

Abstract: Dextran sulfate sodium (DSS)-induced ulcerative colitis is an important method to study ulcerative colitis. This method is widely used in scientific research due to its simple operation, affordable and high modeling success rate. This review summarized the mechanisms of ulcerative colitis induced by DSS, including increase of intestinal permeability, damage of intestinal barrier, cytokines disorder, abnormal signaling pathways and intestinal floras imbalance. Finally, future study directions and ways were prospected.

Key words: dextran sulfate sodium, ulcerative colitis, molding status, mechanisms research