多孔木霉菌的菌丝形态分化与环孢菌素A合成关系的初步研究

doi:10.3969/j.issn.2095-2341.2013.02.12

生物技术进展 ›› 2013, Vol. 3 ›› Issue (2): 140-144.DOI: 10.3969/j.issn.2095-2341.2013.02.12

多孔木霉菌的菌丝形态分化与环孢菌素A合成关系的初步研究

郑孝贤

福建省微生物研究所, 福州 350007

收稿日期:2013-03-02 出版日期:2013-03-25 发布日期:2013-03-15
作者简介:郑孝贤，助理工程师,硕士，研究方向为微生物药物发酵。E-mail：maple2345@sina.com

The Relationship Between Morphological Differentiation and Cyclosporin A Synthesis in Tolypocladium niveum

ZHENG Xiao-xian

Fujian Institute of Microbiology, Fuzhou 350007, China

Received:2013-03-02 Online:2013-03-25 Published:2013-03-15

摘要/Abstract

摘要： 通过对多孔木霉菌在产孢培养基和产菌丝培养基发酵情况的比较,并对整个发酵过程的菌丝形态进行观察,分析多孔木霉菌的菌丝形态分化与环孢菌素A合成的关系。研究表明,环孢菌素A的合成与多孔木霉菌的形态分化密切相关,膨大的菌丝与孢子相互转化过程中,更有利于环孢菌素A的合成。

关键词: 多孔木霉菌, 形态分化, 生理分化, 环孢菌素A

Abstract: The relationship between morphological differentiation and cyclosporin A synthesis in fermentation process of Tolypocladium niveum CA411 was studied. The mycelium and spore morphology changes were observed while Tolypocladium niveum were inoculated in mycelium and sporulation media under the optical microscope. The cyclosporin A synthesis was highly related with morphological differentiation. It's more conducive to the synthesis of cyclosporin A during the process of filamentous hyphae into spore.

Key words: Tolypocladium niveum, morphological differentiation, physiological differentiation, cyclosporin A

郑孝贤. 多孔木霉菌的菌丝形态分化与环孢菌素A合成关系的初步研究[J]. 生物技术进展, 2013, 3(2): 140-144.

ZHENG Xiao-xian. The Relationship Between Morphological Differentiation and Cyclosporin A Synthesis in Tolypocladium niveum[J]. Curr. Biotech., 2013, 3(2): 140-144.

多孔木霉菌的菌丝形态分化与环孢菌素A合成关系的初步研究

The Relationship Between Morphological Differentiation and Cyclosporin A Synthesis in Tolypocladium niveum

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