关键词: 十溴联苯醚, 免疫毒性, 综合生物标志物响应, 自我修复

Abstract: To investigate the immunotoxicity of short-term exposure to decabromodiphenyl ether (BDE-209) and its self-recovery in adult mice, a model of short-term exposure of BDE-209 in female Balb/c mice was established. Organ index, immunoglobulin, lymphocyte proliferation, lipid peroxidation, immune cytokine and genes were investigated on 1 d and 21 d after the end of administration, respectively. And integrated evaluation was conducted by integrated biomarker responses combined with principal component analysis and factorial analysis. The results showed that BDE-209 could reduce the index of immune organs, accompanied by oxidative damage. BDE-209 could stimulate the secretion of IgG and inhibit the proliferation of spleen lymphocytes. BDE-209 could change the secretion of cytokines and gene expression related to Th1 and Th2 cells, causing Th1/Th2 imbalance. The comprehensive analysis showed that the immunotoxicity of BDE-209 was reduced 21 days after the end of exposure, and there was an interaction between the exposure dose of BDE-209 and whether the recovery period was passed. The results showed that short term exposure to BDE-209 has immunotoxicity in adult mice, but this effect could be reduced to some extent by self-recovery.

Key words: decabromodiphenyl ether, immunotoxicity, integrated biomarker responses, self-recovery