转基因耐除草剂大豆的食用安全评价研究进展

doi:10.19586/j.2095-2341.2021.0034

生物技术进展 ›› 2021, Vol. 11 ›› Issue (4): 489-495.DOI: 10.19586/j.2095-2341.2021.0034

转基因耐除草剂大豆的食用安全评价研究进展

张凤¹(), 贺晓云¹^,², 黄昆仑¹^,², 汪其怀³()

^1.中国农业大学食品科学与营养工程学院，北京 100083
^2.农业农村部农业转基因生物安全评价（食用）重点实验室，北京 100083
^3.农业农村部科技发展中心，北京 100176

收稿日期:2021-03-16 接受日期:2021-04-14 出版日期:2021-07-25 发布日期:2021-08-02
通讯作者: 汪其怀
作者简介:张凤 E-mail：zhangfengyx818929@163.com；
基金资助:
国家转基因生物新品种培育重大专项(2016ZX08011-005)

Food Safety Evaluation of Transgenic Herbicide Tolerant Soybean

Feng ZHANG¹(), Xiaoyun HE¹^,², Kunlun HUANG¹^,², Qihuai WANG³()

^1.College of Food Science and Nutritional Engineering，China Agricultural University，Beijing 100083，China
^2.Key Laboratory of Safety Assessment of Genetically Modified Organisms（Food Safety），Ministry of Agriculture and Rural Affairs，Beijing 100083，China
^3.Development Center of Science and Technology，Ministry of Agriculture and Rural Affairs，Beijing 100176，China

Received:2021-03-16 Accepted:2021-04-14 Online:2021-07-25 Published:2021-08-02
Contact: Qihuai WANG

摘要/Abstract

摘要：

转基因大豆是目前种植最广泛的转基因作物之一，其中具有耐除草剂特性的转基因大豆占比最高。公众对转基因食品一直争议不断，因此，其批准商业化种植前的食用安全性评价显得尤为重要。已有研究显示，转基因耐除草剂大豆已经商业化种植了二十多年，迄今为止还没有观察到任何不良反应。目前已经批准的转基因耐除草剂大豆均进行了严格的毒理学评价、过敏性评价和营养学评价，经过严格评价后上市的转基因大豆可以放心食用。综述了转基因耐除草剂大豆的主要类型，分析了可能存在的安全性问题，对转基因耐除草剂大豆的食用安全性评价方法进行了总结，以期为后续相关转基因食品安全性评价工作的开展提供借鉴。

关键词: 转基因大豆, 耐除草剂, 食用安全性, 安全性评价

Abstract:

Transgenic soybean is one of the most widely planted transgenic crops， in which the proportion of transgenic soybean with herbicide tolerance is the highest. The public has been arguing about genetically modified food for a long time. Therefore， it is very important to evaluate food safety before commercial planting. Studies have shown that transgenic herbicide?tolerant soybean has been commercially planted for more than 20 years， no adverse reactions have been observed so far. At present， the approved transgenic herbicide?tolerant soybeans have been strictly evaluated in toxicology， allergy， and nutrition. After that， transgenic soybean can be safely consumed. The main types of transgenic herbicide?tolerant soybean were summarized， and the possible safety problems were analyzed. The food safety evaluation methods of transgenic herbicide?tolerant soybean were summarized. This paper was expected to provide references for the follow?up work of genetically modified food safety evaluation.

Key words: transgenic soybean, herbicide tolerance, food safety, safety evaluation

中图分类号:

S565.1

张凤, 贺晓云, 黄昆仑, 汪其怀. 转基因耐除草剂大豆的食用安全评价研究进展[J]. 生物技术进展, 2021, 11(4): 489-495.

Feng ZHANG, Xiaoyun HE, Kunlun HUANG, Qihuai WANG. Food Safety Evaluation of Transgenic Herbicide Tolerant Soybean[J]. Current Biotechnology, 2021, 11(4): 489-495.

图/表 1

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耐除草剂类型	性状	目的基因	转基因生物体
耐有机磷类除草剂	耐草甘膦	cp4‑epsps/2mepsps/gat4601	GTS40‑3‑2/MON89788等
耐有机磷类除草剂	耐草铵膦	Pat/bar	A2704‑12/ W62 /GU262等
耐苯甲酸类除草剂	耐麦草畏	dmo	MON87708等
耐激素类除草剂	耐2，4D	add‑12	DAS44406‑6/DAS68416‑4等
耐磺酰脲类除草剂	耐磺酰脲类	gm‑hra	DP305423等
耐咪唑啉酮类除草剂	耐咪唑啉酮类	csrl‑2	CV127
耐异噁唑草酮类除草剂	耐异噁唑草酮类	Hppdpf w336	FG72
耐多种除草剂	耐草甘膦+耐磺酰脲类	gat4601+ gm‑hra	DP356043
	耐草甘膦+耐异噁唑草酮	2mepsps+Hppdpf w336	FG72
	耐草甘膦+耐麦草畏	cp4‑epsps+dmo	MON87708
	耐草铵膦+耐2，4D	add‑12+pat	DAS68416‑4
	耐草铵膦+耐甲基磺草酮	pat+avhppd‑03	SYHT0H2
	耐草铵膦+耐草甘膦+耐2，4D	add‑12+2mepsps+pat	DAS44406‑6
	耐草铵膦+耐草甘膦+耐异噁唑草酮	2mepsps+Hppdpf w336+pat	FG72×A5547‑127
	耐草铵膦+耐草甘膦+耐麦草畏	cp4‑epsps+dmo+pat	MON87708×MON89788×A5547‑127

耐除草剂类型	性状	目的基因	转基因生物体
耐有机磷类除草剂	耐草甘膦	cp4‑epsps/2mepsps/gat4601	GTS40‑3‑2/MON89788等
耐有机磷类除草剂	耐草铵膦	Pat/bar	A2704‑12/ W62 /GU262等
耐苯甲酸类除草剂	耐麦草畏	dmo	MON87708等
耐激素类除草剂	耐2，4D	add‑12	DAS44406‑6/DAS68416‑4等
耐磺酰脲类除草剂	耐磺酰脲类	gm‑hra	DP305423等
耐咪唑啉酮类除草剂	耐咪唑啉酮类	csrl‑2	CV127
耐异噁唑草酮类除草剂	耐异噁唑草酮类	Hppdpf w336	FG72
耐多种除草剂	耐草甘膦+耐磺酰脲类	gat4601+ gm‑hra	DP356043
	耐草甘膦+耐异噁唑草酮	2mepsps+Hppdpf w336	FG72
	耐草甘膦+耐麦草畏	cp4‑epsps+dmo	MON87708
	耐草铵膦+耐2，4D	add‑12+pat	DAS68416‑4
	耐草铵膦+耐甲基磺草酮	pat+avhppd‑03	SYHT0H2
	耐草铵膦+耐草甘膦+耐2，4D	add‑12+2mepsps+pat	DAS44406‑6
	耐草铵膦+耐草甘膦+耐异噁唑草酮	2mepsps+Hppdpf w336+pat	FG72×A5547‑127
	耐草铵膦+耐草甘膦+耐麦草畏	cp4‑epsps+dmo+pat	MON87708×MON89788×A5547‑127

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转基因耐除草剂大豆的食用安全评价研究进展

Food Safety Evaluation of Transgenic Herbicide Tolerant Soybean

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