Piezo1在癌症中的作用研究进展

doi:10.19586/j.2095-2341.2023.0016

生物技术进展 ›› 2023, Vol. 13 ›› Issue (5): 712-717.DOI: 10.19586/j.2095-2341.2023.0016

Piezo1在癌症中的作用研究进展

安外尔·约麦尔阿卜拉(), 孙莉莉, 布尔兰·叶尔肯别克, 郭文佳()

新疆医科大学附属肿瘤医院，乌鲁木齐 830001

收稿日期:2023-02-17 接受日期:2023-08-01 出版日期:2023-09-25 发布日期:2023-10-10
通讯作者: 郭文佳
作者简介:安外尔·约麦尔阿卜拉 E-mail： anwar1118@163.com；
基金资助:
新疆维吾尔自治区自然基金杰出青年科学基金项目(2022D01E27);新疆医科大学“优秀青年”项目(2021YQ001)

Advances on the Role of Piezo1 in Cancer

Yuemaierabola ANWAIER(), Lili SUN, Yeerkenbieke BUERLAN, Wenjia GUO()

Affiliated Cancer Hospital of Xinjiang Medical University，Urumqi 830001，China

Received:2023-02-17 Accepted:2023-08-01 Online:2023-09-25 Published:2023-10-10
Contact: Wenjia GUO

摘要/Abstract

摘要：

Piezo1是机械敏感压电离子通道家族的成员，能够将各种机械刺激转换为电化学信号。在几种恶性肿瘤中Piezo1作为致癌介质起重要作用，它通过多种机制介导多种癌细胞的增殖、迁移和侵袭。多项研究表明，Piezo1的表达与衰老和癌症患者的临床特征有关，使Piezo1有望成为一种新的生物标志物。综述了Piezol的结构、Piezol通道的动力学特性及其在癌症中的作用，以期为Piezo1用于多种癌症的诊断和预后判断以及作为肿瘤生物标志物和治疗靶点提供参考依据。

关键词: Piezo1, 作用机制, 肿瘤生物标志物, 治疗靶点

Abstract:

Piezo1 is a family member of mechanically sensitive piezoelectric ion channels that convert various mechanical stimuli into electrochemical signals. Piezo1 plays an important role in several malignant tumors as a carcinogenic medium， mediating the proliferation， migration and invasion of various cancer cells through various mechanisms. Several studies have linked the expression of Piezo1 to the clinical characteristics of aging and cancer patients， making Piezo1 promising as a new biomarker for the diagnosis and prognosis of several human cancers. This paper summarized the structure of Piezo1， dynamic characteristics of the Piezo1 channel and its function in cancer， which was expected to provide reference for Piezo1 used in diagnosis and prognosis of cancer and tumor biomarker and therapeutic target.

Key words: Piezo1, mechanism of action, tumor biomarker, therapeutic target

中图分类号:

Q986

安外尔·约麦尔阿卜拉, 孙莉莉, 布尔兰·叶尔肯别克, 郭文佳. Piezo1在癌症中的作用研究进展[J]. 生物技术进展, 2023, 13(5): 712-717.

Yuemaierabola ANWAIER, Lili SUN, Yeerkenbieke BUERLAN, Wenjia GUO. Advances on the Role of Piezo1 in Cancer[J]. Current Biotechnology, 2023, 13(5): 712-717.

图/表 2

参考文献 46

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Piezo1在癌症中的作用研究进展

Advances on the Role of Piezo1 in Cancer

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