Abstract：Y chromosome short tandem repeats （Y-STRs） can serve as a promising and useful supporting tool in forensic research, especially in the analysis of male components of mixed stains and pedigree examination. With the development of Y-STR commercial kits and the establishment of databases, numerous studies on Y-STR polymorphism in different regions and populations is increasing. However, there are few reports on the Y-STR related study of Tongchuan Han population. Based on this, the genetic polymorphisms of 38 Y-STR loci in 669 unrelated healthy male individuals in Tongchuan Han population in Shaanxi province was investigated by YfilerTM Platinum Multiplex Amplification Kit, and the genetic relationship between Tongchuan Han nationality and other populations was explored. A total of 657 unique haplotypes were observed in Tongchuan Han population. Haploid diversity and discrimination power were 0.999 937 345 and 0.982 1, respectively. 428 alleles were detected in 38 Y-STR loci, with the gene diversities ranging from 0.108 9 (DYS645) to 0.969 9 (DYS385). Genetic distance, multi-dimensional scaling (MDS) and phylogenetic tree were consistent that the population relationship between Tongchuan Han population and other Han groups from different geographical regions was close. In conclusion, the forensic genetic parameters obtained based on 38 Y-STR loci had a high genetic polymorphism in Tongchuan Han population, which had potential application value in inferring male suspects in forensic crime scene in Tongchuan.
靳涛1,田杨1,全言钊1,李明亮1,严安心2,李璐瑶3*. 铜川汉族人群38个Y-STR基因座多态性调查[J]. 生物技术进展, 2021, 11(2): 223-230.
JIN Tao1, TIAN Yang1, QUAN Yanzhao1, LI Mingliang1, YAN Anxin2, LI Luyao3*. #br#
Analysis of Genetic Polymorphisms at 38 Y-STR Loci in Tongchuan Han Population. Curr. Biotech., 2021, 11(2): 223-230.